One of the most common potentially premalignant condition in India is Oral submucous fibrosis (OSMF) with 3-6% of malignant transformation. Habits of betel nut, tobacco, smoking, and pan masala have shown a close association with the occurrence of OSMF. The characteristic feature of OSMF is the progressive hyalinization of the submucosa leading to reduced mouth opening. Various treatment modalities including drug therapy, surgical therapy, and physiotherapy have been proposed till date for the management of OSMF although optimal doses of local injection with corticosteroids, hyaluronidase, and local anesthesia had shown significant reduction in the clinical symptoms. As photobiomodulation is an emerging minimally invasive therapy which can utilized for the treatment of OSMF thorough its anti- inflammatory and analgesic effect. This article is to report a case of OSMF, which was treated with a combination therapy of photobiomodulation and intralesional injection of triamcianalone acetonide and hyaluronidase and gave better results in terms of improved mouth opening and reduction in burning sensation.