Liver diseases pose significant health challenges globally, necessitating the exploration of effective natural hepatoprotective agents. This study investigates the hepatoprotective effects of Azadirachta indica (neem) leaf extract and evaluates its potential synergistic benefits when combined with other herbal extracts. Using a murine model of chemically induced hepatotoxicity, we assessed the effects of Azadirachta indica leaf extract through biochemical assays, oxidative stress measurements, and histopathological evaluations. The results demonstrate significant hepatoprotective effects, suggesting that Azadirachta indica could be a valuable natural therapeutic agent for liver protection.