The term infantile or prenatal macrosomia is still a context of medical interest till now. Main causes of macrosomia might be concluded as: diabetic mother prolonged pregnancy, maternal hypertension and male sex infant, race and genetic factors, multiparous pregnant, old prenatal age particularly at old marital age and extraordinary prenatal mother body mass index, indeed mother obesity is regarded as one of the chief risk factor. Also previous delivery of macrosomic fetus, in addition to some foetal genetic causes like Weaver syndrome, Sotos syndrome, Beckwith – Weiderman syndrome and Fragile X syndrome.