The paper discusses the importance of soybean as a staple food and the need to increase crop production to meet the demands of a growing population. It highlights the challenges posed by abiotic and biotic stresses on soybean plants, such as drought, salinity, temperature, pests, and diseases. The paper also discusses the use of synthetic plant nutrients and chemicals to overcome these challenges, but highlights the negative impacts of prolonged usage on soil and the environment. The paper suggests that biological methods, such as plant genetic engineering and biofertilizers, offer promising solutions for promoting crop production in a sustainable and eco-friendly manner. It emphasizes the role of plant growth promoting rhizobacteria (PGPR) in enhancing plant growth and defense mechanisms through interactions with the plant's root system and secretion of beneficial compounds. The paper proposes further research on the molecular mechanisms underlying plant-PGPR interactions and the impact of root exudates on these interactions. The ultimate goal is to identify candidate genes and develop eco-friendly approaches to enhance crop production. © 2024 Mariyam Ansari, This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Creative Commons license, and indicate if changes were made