Three series of quinoline derivatives with pyrazole moiety have been developed in an effort to create novel antibacterial drugs. Have been synthesized from 2,8-dichloroquinoline-3-carbaldehyde converted into1-(2,8-dichloroquinoline-3-yl)-N-phenylmethanimine. Which is cyclised by hydrazine and conc.HCl to gives 1-(8-chloro-2-hydrazinylquinolin-3-yl)-N-phenylmethanimine it was reacted with ethylaceto acetate gives 1-{8-chloro-3-[(phenylimino)methyl]quinolin-2-yl)-3-methyl-1 H-pyrazol-5-ol derivatives. Hydrazides were created in order to try and reduce the resistance that arose as a result of the drug's decreased exocytosis concentration. These synthetic compounds underwent a preliminary biological assessment. Using IR, 1HNMR, and mass spectroscopy, the produced compounds were identified and characterized. By using the cup plate method to assess the compounds' antibacterial activity, MSBSM-VC and MSBSM-VE demonstrate notable antimicrobial activity.