Seven novel organotellurium derivatives of carboxylic acids have been synthesized by the reaction of 1, 1-diiodo-1-telluracyclopentane, 1, 1-diodo-2-methyl-1-telluracyclopentane, and 1,1-diiodo-1,1-diethyltellurium (IV) with silver salts of corresponding carboxylic acids in 1:1/ 1:2 molar ratio. The characterization of the synthesized organotellurim carboxylates was carried out using IR spectroscopy, NMR (1H & 13C{1H}) spectroscopy, and elemental analysis. The results of these studies suggested the general formula of the compounds as [R2Te(OCOR’)2], and [R2Te(OCO)2R”] (where R2= C4H7 (CH3), C4H8, (C2H5)2; R’= CH3, CH=CHC6H5; (OCO)2R”= (OCO)2, (OCO)2C6H4. The compounds were screened against P. aeruginosa, E. coli, S. aureus, and K. pneumoniae using broth microdilution and agar disc diffusion methods. Only two compounds showed significant activity at lower concentrations against all tested bacterial strains. However some others showed potent activity against specific bacterial strains