Synthesis of water-soluble imidazole derivatives which is attached with base sensitive fluorophore peripheral units with different organic compounds under conventional and silica supported Muffle furnace methods. Solvent free synthetic approach has more merits than the conventional method, such as non-toxic, shorter reaction time, easy workup procedure without purification process and higher yields. Synthesized substituted imidazole derivatives are acted as excellent catalytic response for the preparation of Gem-bisamides derivative under conventional approach.