Background: The management of postoperative inflammation is a critical aspect of achieving successful outcomes in cataract surgery. Over the last decade, nonsteroidal anti-inflammatory drugs (NSAIDs) have gained widespread popularity in the postoperative setting, often being prescribed in conjunction with corticosteroids. This study aims to present a systematic review and case report of inflammation management in cataract surgery involving 59 year old male with senile cataract and glaucoma. Methods: The study adhered to PRISMA 2020 standards, examining English literature from 2014 to 2024. It excluded editorials, reviews from the same journal, and submissions without a DOI. PubMed, SagePub, SpringerLink, and Google Scholar were utilized as literature sources. Case Management: A 59-year-old male patient presented to Randegansari Husada Hospital, Gresik Regency with a five-year history of worsening blurry vision, primarily in the right eye, with recent dizziness and no significant pain. Diagnosed with immature senile cataract and secondary glaucoma, he underwent successful phacoemulsification surgery with improved visual acuity postoperatively. Result: Initially retrieving 500 articles from online databases (PubMed, SagePub, SpringerLink and Google Scholar) five relevant papers were selected after three rounds of screening for full-text analysis. Conclusion: Combining NSAIDs and corticosteroids shows promise in managing postoperative inflammation and reducing intraocular pressure after cataract surgery. Newer delivery systems may further enhance recovery outcomes and improve patient care