ISSN : 2663-2187

The Analysis Study of Obesity-related hypertension and chronic kidney disease : A Comprehensive Systematic Review and Metaanalysis Study

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Calista Giovani, Theodora Monica Carissa, Claudia Priska Adelin
» doi: 10.48047/AFJBS.6.Si2.2024.5183-5201

Abstract

Background: Obesity poses significant challenges to healthcare globally, particularly through its bi‐directional relationship with co‐morbid metabolic conditions such as type 2 diabetes and hypertension. There is also emerging evidence of an association between obesity and chronic kidney disease (CKD) which is less well characterized. Method: This systematic review and meta-analysis, conducted following PRISMA guidelines and employing the PICO format, aim to explore about the analysis study of obesity related hypertension and chronic kidney disease. Inclusion criteria encompass diverse study designs (RCTs, observational, quasi-experimental, and case-control studies) investigating obesity related hypertension and chronic kidney disease, while exclusion criteria filter out studies lacking relevance to obesity related hypertension and chronic kidney disease. Result: After three levels of screening, 10 articles directly relevant to the systematic review were chosen for full-text analysis. The selected articles, demonstrate a recent publication trend, with 3 are articles published in PubMed journal, 2 were published in Sage Journal, 2 were published in Lancet, 3 were published in Science Direct from 2014 – 2024. Conclusion: Obesity may predispose to CKD directly as it is linked to the histopathological finding of obesity‐related glomerulopathy and indirectly through its widely recognized complications such as atherosclerosis, hypertension, and type 2 diabetes.

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