Background and objectives:Although increase in body fat is a recognized risk factor for the development of lower limb venous disease, minimum attention has been given to identify and measuring the effect of obesity on hemodynamic vascular changes related to blood flow in the lower limbs. Patients and methods:The diameter of lower limb veins and venous blood flow were measured in 207 patients having larger BMI than normal and chronic venous disease. Results: there was a strong positive correlation between weight and BMI and qualified perforator diameter. Other changes such as GSV and SSV diameter show no significant relationship with obesity, weight and age. Conclusions: These data shows that obesity has a positive correlation with both structural and hemodynamic changes in the lower limb veins.