The study aimed to observe the effect of SGLT2 inhibitors in heart failure patients. It is a prospective observational study design; with this method, the researcher selected 40 samples from department of cardiology at Banjara Hills, Hyderabad Care Hospital. The result showed that after the addition of SGLT2 inhibitors in cardiac patients (subset of HFpEF and HFrEF ) has reduced symptomatic effect of heart failure,SGLT2 inhibitors Proven to lower blood pressure by 2%,SGLT2 inhibitors reduced HbA1C levels by 2%,Its incidental observation of Reduction in body weight with SGLT2 inhibitors usage ,Diuretic effect observed by correction of dilutional hyponatremia and reduction in serum potassium levels with SGLT2 inhibitors,5% ADRs observed like increased incidence of UTI in patients with SGLT2 inhibitors, Appropriate measures for screening in at risk population should be suggested before initiating the drug.so, the usage of SGLT2 inhibitors is a new pharmacological application effective in the treatment of DM and NON- DM and associated with heart failure.