Gastritis is defined as inflammation of gastric mucosa. Gastritis can be classified as acute gastritis and chronic gastritis. According to various studies, there is an increasing trend of gastritis among students. Level of students knowledge and use of self-medication is still lacking, one of which is the adoption of unhealthy lifestyle. Factors responsible for this are H. pylori, anxiety, stress, food habits, self-medication and lack of knowledge among students eventually leads to local ischemia of gastric mucosa, elevation of gastric pH, hypergastrinemia and hyperplasia of antral gastrin producing G-cells which brings mucosal injury causing gastritis. This type of research is observational. The data collected is in the form of quantitative data using a survey method with a questionnaire as the main instrument. The results show that percentage prevalence of self-medication practices with gastritis was 35.3% in males and 64.7% in females. Total 456 students from which 192 are medical students and 264 are non-medical students out of these 309 students practiced self medication that means most of non-medical students practiced self medication these are 117 students of non-medical. So, the level of student’s knowledge and use of self-medication practices of medical vs. non-medical students is 67.7% which is satisfactory.