Objective Iron deficiency anemia is common in females and might lead to depressive disorders as well. Therefore, this study was conducted to assess the association of iron deficiency anemia with depressive disorders. It was further aimed to find out the relation of severity of anemia with depressed symptoms. Method This case control study was conducted by using non probability convenient sampling technique. A sample of females aged between 18 to 40 years were recruited and divided into two groups: one with diagnosed iron deficiency anemia and another without it. Data was collected through standardized psychological assessment tools and structured interviews. This study was undertaken at Omair sana foundation in Karachi from December 2023 to February 2024.The sample size estimation revealed 400 participants. Out of them 200 were anemic and 200 were healthy controls. Ethical clearance was obtained, and individuals gave informed consent. The data was analyzed using statistical tests by using SPSS version 26. Quantitative data was expressed as mean and standard deviation, whereas qualitative data was presented as frequency and percentages. Chi-square test was used to assess the association, with a significance level of p < 0.05.