Nuclear Factor-κβ (NF-κβ) is a key molecule involved in regulating inflammation, immune responses, and cancer progression. Its role in invasive breast cancer has become an important focus in recent research due to its influence on tumor growth, survival, and spread. This review examines the value of NF-κβ as an immunohistochemical marker in breast cancer diagnosis and prognosis. We explore how NF-κβ expression in breast cancer tissues is linked to clinical and pathological factors such as tumor size, grade, lymph node involvement, hormone receptor status, and patient survival outcomes. Additionally, the review discusses the potential of NF-κβ to predict responses to treatment, particularly chemotherapy and targeted therapies. By analyzing existing studies, we provide insights into how NF-κβ functions both to promote and, in some cases, suppress tumor activity, reflecting its complex role in cancer biology. This review emphasizes the potential of NF-κβ as a valuable biomarker for guiding breast cancer management while highlighting the need for further research to better define its clinical utility and standardize its assessment.