Black Stone Flower (Parmotrema perlatum) or Kalpasi, is a lichen that has been traditionally utilized in various parts of the world for its therapeutic properties. This paper aims to prospect the therapeutic benefits of Black Stone Flower, focusing on its phytochemical constitution, antimicrobial properties, anti-inflammatory effects, and promising applications in modern medicine. By integrating recent research and traditional usage, this study provides a thorough overview of the potential health benefits of this unique lichen