Aim: To investigate the susceptibility of Candida isolates from the urine of hospitalized patients to antifungal agents. Material and methods: The study included a total of 2123 hospitalized patients who had their urine samples submitted for culture and sensitivity testing. Out of these, 100 patients were found to be positive for Candida species, and these 100 Candida-positive samples formed the basis of the study. For the culture, urine samples were cultured on Sabouraud Dextrose Agar (SDA) and incubated at 37°C for 24-48 hours. The colonies were further identified to the species level using chromogenic agar, germ tube test, and VITEK 2 system (bioMérieux, France). The antifungal susceptibility of the Candida isolates was determined using the Clinical and Laboratory Standards Institute (CLSI) M27-A3 broth microdilution method. The antifungal agents tested included Fluconazole, Itraconazole, Voriconazole, Amphotericin B, Caspofungin, and Micafungin. Results: - Candida tropicalis, Candida parapsilosis, and Candida krusei were less common, each representing 15%, 10%, and 10% of the isolates, respectively. For Candida albicans, 75% of the isolates were susceptible to fluconazole, while 25% were resistant. Itraconazole showed a 70% susceptibility rate, with 30% resistance. Voriconazole was effective against 88% of the isolates, and amphotericin B had the highest susceptibility rate at 95%. Candida glabrata had 40% resistance to fluconazole and 52% to itraconazole. However, it remained largely susceptible to voriconazole (80%), amphotericin B (88%), caspofungin (84%), and micafungin (92%). Candida tropicalis had 67% of isolates susceptible to fluconazole and 60% to itraconazole. Candida parapsilosis isolates showed 80% susceptibility to fluconazole, 70% to itraconazole, 90% to voriconazole, and 90% to both amphotericin B and micafungin. Candida krusei, had 70% susceptibility to itraconazole, voriconazole, and caspofungin, while amphotericin B and micafungin showed 70% and 80% susceptibility, respectively.