Transcranial direct current stimulation (tDCS) is a non-invasive tool that induces neuromodulation in the brain. Day by day it is becoming very popular method of treatment in physical therapy practice to manage various neuromusculoskeletal condition. Therefore, the primary aim of this systematic review was to summarize the role of tDCS to manage various neuro-musculoskeletal conditions in physical therapy practice. Methods: Following PRISMA guidelines, a computer-based literature search was conducted in four databases from 1996 to 2022 Randomized control trials were carried out that evaluated the effects of transcranial direct current stimulation (tDCS) on neuro-musculoskeletal conditions, including osteoarthritis, cerebral palsy, parkinsonism, spinal cord injury stroke, migraine fibromyalgia, low backache, etc. The qualities of the trials were assessed using the PEDro scale. Results: Thirteen randomized control trials were included in this review. The results indicated that the tDCS significantly affects osteoarthritis, cerebral palsy, parkinsonism, spinal cord injury stroke, migraine fibromyalgia, and low backache when given with a combination of physical therapy interventions. Conclusion: tDCS is found to be an effective intervention with good outcomes in participants when given in combination with physiotherapy in neuro-musculoskeletal disorders.