Polyetheretherketone (PEEK) is a modern, innovative high performance polymer material which has proven to be successful in many areas of dentistry and a promising alternative to metal in fixed partial dentures along with removable prosthesis due to its toughness, based on its properties similar to bone. This systematic review highlights the characteristics, prosthodontic applications and future prospects of PEEK in the field of clinical dentistry. Methods: A retrospective literature searches which spanned from April 1990 through August 2023 were performed using the keywords “PEEK”, “polyetheretherketone”, “dentistry”, “dental implant” on the Medline via Pubmed, Scopus and Google Scholar databases. Search included in-vitro and in-vivo studies published in English language and the relevant articles of references were also analyzed and summarized. Results: A great number of in vitro studies with only few clinical studies were found and data obtained were organized according to characteristics of PEEK and its different applications in dentistry. PEEK was recommended for fixed, removable and implant prosthesis along with other uses like, occlusal splints, intra-radicular posts, customized healing abutments and provisional restorations. Conclusion: PEEK is a high and innovative approach with prosthetic solution for removable, fixed and screw retained prosthesis. In the near future, PEEK is expected to be a clinical alternative to the use of metal even in crown and bridges along with traditional dentures and more clinical studies are needed in the same direction