Systemic lupus erythematosus (SLE) presents a diagnostic and therapeutic challenge due to its diverse clinical manifestations and relapsing-remitting course. This review delves into the complexities of SLE, highlighting its predilection for young females and potential to affect any organ system. We explore the spectrum of clinical presentations, ranging from common symptoms like rash, fatigue, and arthritis to severe complications involving the kidneys, nervous system, and blood cell counts. The cornerstone of management is focusing on controlling acute flares, preventing future relapses, and alleviating daily symptoms. We discuss the crucial role of serological tests and tissue biopsies in establishing a definitive diagnosis. This case series presents [Number] cases of Systemic Lupus Erythematosus (SLE) diagnosed and managed at our institution. The series aims to illustrate the diverse clinical presentations of SLE.