Background: Tumor microenvironment has elevated levels of extracellular acidity as a result of its glycolytic nature. Aim: The aim of the study is to analyse whether oral administration of sodium bicarbonate can prevent cancer by increasing the tumor pH and controlling tumor invasion and metastases through various experimental research. Materials and Methods: In this study, the electronic databases were searched from the time of their conception until 2023, in compliance with PRISMA guidelines. Original studies conducted among experimental mice, were given sodium bicarbonate orally, which was found to be a significant global cancer prevention strategy. Result and Conclusion: The result shows that oral administration of sodium bicarbonate prevents cancer progression in mice by increasing the tumor pH. However, more clinical trials are required to show its efficacy in patients as an adjuvant therapy or a stand-alone treatment. Furthermore, it is necessary to look at patients' sodium bicarbonate tolerance and safety.