Introduction: The clinico-demographic profile of COPD patients encompasses a wide range of variables, including age, gender, socioeconomic status, comorbidities, and symptomatology. Cigarette smoking is the primary risk factor contributing to the development of COPD. Aim and objectives: To study clinico- demographic and lung spirometry profile between non-smoker and smoker COPD patients. Material and methods: This is a cross-sectional observational study, conducted in 200 clinically diagnosed COPD patients attending the pulmonary medicine department at PCMS & RC between the November 2022 to February 2024; after getting approval from the institutional ethical committee. All the data analysis was performed using IBM SPSS ver. 25 software. Observations & results: The mean (±SD) age of total 200 patients were 58.43±10.07 years, of these maximum 35% (71) patients were belonged to 51 – 60 years age group. 67% were smokers and 33% were non-smokers, most of COPD patients (35%) were farmers and most 58.5% were resides in rural areas. Smokers showing statistically significant more shortness of breath compared to non-smokers. Conclusion: We concluded that COPD is more common in smokers, in non-smokers biofuel and second-hand smoke are key risk factors, especially in rural areas and this is the highlighting need for public health interventions.