There are many chronic disorders that have troubled the humankind, hypercholesterolemia probably stands first in the queue of being the root cause of most diseases effecting the heart, kidney, brain and blood vessels. Developing because of unhealthy eating habits, sedentary lifestyle and affecting mostly financially privileged class of society, it has contributed enormously to the global health burden. Scientists have come up with considerable numbers of both synthetically derived and naturally derived therapeutic agents to halt the detrimental effects of this disorder that only gets worse over time. Some of these drugs, such as Rosuvastatin and Atorvastatin have been used quite efficiently and they provide multi- dimensional protection to the human body. While others such as PCSK9 inhibitors and ANGPTL 3 inhibitors provide even better alternative to already existing therapies. Despite these excellent agents, the efficacy and potency of herbal derived products cannot be neglected and prove to be extremely popular among general populace to counter this disorder. In this review, we lay down epidemiology, pathophysiology and lipid lowering drugs, both synthetic and herbal.