Background Candida infections often happen in the mouth. These types of germs can create thin layers that can grow inside the mouth, braces, brackets, and false teeth. In this study, Aurantoside-G, taken from the marine sponge Theonellaswinhoei, was compared to Clotrimazole. It was tested against important antigens from Candida albicans. Methods GLIDE 4. 0 software was used to check how well the ligands and targets fit together in this study. The shapes of the molecules Aurantoside-G and Clotrimazole were found in the PubChem database and created using the ChemDraw program. The target protein from the Candida albicans antigens, called δ-14-sterol reductase (4QUV), used in this study was taken from the Protein Data Bank. The ligands and targets were studied and organized using the PymoL viewer. The GLIDE program was used to fit the ligand and target together. Result In this study, the weight of Aurantoside-G was found to be 344. 84 grams per mole and the weight of Clotrimazole was found to be 743. 15 grams per mole. Aurantoside-G has 1 hydrogen bond acceptor, while Clotrimazole has 15. Aurantoside-G has no H-bond donors, while Clotrimazole has 8. Aurantoside-G did not dissolve in water, but Clotrimazole dissolved very well. Aurantoside-G was more effective than Clotrimazole. Conclusion The final docking results show that Aurantoside-G had a much higher docking score and is similar in drug qualities to Clotrimazole. In the future, more tests on how drugs work might help develop Aurantoside-G as a treatment for yeast infections.