Introduction: The irrational use of medicines is a global issue that negatively impacts both the health and the economy of countries. India, in particular, faces the challenge of managing infectious diseases with limited economic resources. Therefore, conducting a drug utilization study is crucial to analyse the prescribing patterns and identify problems associated with medication usage. Methods: This cross-sectional study examined general practitioners' prescriptions in a rural South Indian area. A total of 545 outpatients who visited clinics over three months were included in the study. All prescriptions from patients of all ages and genders in the specific district were collected, involving general practitioners with MBBS degrees. Only outpatient prescriptions were considered, resulting in a total of 950 prescriptions. Over the counter (OTC) drug details were obtained from the pharmacy register that served the clinic area. Practitioners who did not give consent to participate were excluded. Results: The analysis revealed that out of the total drug consumption, 89% comprised over the counter (OTC) drugs, while 11% were exclusively prescribed medications. Among the prescribed drugs, 69% were nonantimicrobials, and 31% were antimicrobials. Notably, Proton Pump Inhibitors were highly prescribed, accounting for 69% of non-antimicrobial prescriptions. Among the prescribed antimicrobials, the third-generation cephalosporin, cefixime, was predominantly used, comprising 64% of microbial prescriptions. In the OTC drug category, non-antimicrobials represented 79% of consumption, while antimicrobials accounted for 21%. Additionally, injections constituted approximately 51% of all prescription drugs overall. Conclusion: This study provides valuable insights into the drug utilization trends and prescription patterns in rural India, which is a vulnerable demographic. It also enables the analysis of appropriate drug dispensing and usage to optimize antimicrobial therapy while promoting generic drug prescriptions.