Introduction: The nuclear factor kappa B (NF-kappa B, NF-κB), a nuclear protein is a major eukaryotic transcription factor, located mainly in the brain, also in the neutrophils, mainly found in all nucleated cells. Several transcription factors are present at the synapse, and among these are the Rel-NF-kappa B pathway components. NF-kappa B is a constitutive transcription factor, found only in cells that transcribe immunoglobulin light chain genes that interact with a defined site in the κ immunoglobulin enhancer.