Chrono-modulated drug delivery systems have become a potentially useful approach for optimizing therapeutic outcomes by synchronizing drug administration with circadian rhythms and disease patterns. The circadian rhythm regulates various physiological processes, including drug absorption, distribution, metabolism, and elimination. Chrono-modulated drug delivery systems involve the controlled release of drugs at particular intervals to correspond with the body's natural rhythm. Two-thirds of asthma patients have nocturnal asthma, which is characterized by an increase in symptoms such as wheezing, tightness in the chest, increased reactivity of the airways, and deterioration of lung function during the night. Between midnight and 8:00 am, and particularly around 4:00 am, these symptoms manifest. Several strategies have been explored for designing chrono modulated drug delivery systems, such as implantable devices, transdermal patches, and oral formulations with specialized release profiles. These systems incorporate various mechanisms, including pH-sensitive coatings, osmotic pumps, and programmable electronics, to achieve the desired temporal release pattern. The benefits of chrono-modulated drug delivery systems are extensive. By targeting drug administration during specific periods of disease activity or maximum need, therapeutic concentration levels can be optimized, leading to improved patient outcomes. Furthermore, by minimizing drug exposure during inactive disease phases, side effects and drug resistance can potentially be reduced. This review also highlights the challenges associated with developing chrono modulated drug delivery systems, including formulation stability, release rate control, and regulatory approvals.