Background: Molar pregnancy is the most common form of gestational trophoblastic disease with a high incidence also associated with a high risk of choriocarcinoma.There is interobserver and intraobserver variablilities in histopathologically classifying this disease. To overcome this difficulty, expression of p57 and Ki-67 are used to categorize the entities. Materials and methods: Total of 80 cases were included in this study, out of which 27 (33.45%) were complete moles, 23 (28.75%) partial moles and 30 (37.5%) hydropic abortus on Hematoxylin and Eosin (H&E) stain, 4 cases (2 HA and 2 PHM cases) showed discordance on p57 and Ki-67 immunostaining, hence were not included in the statistical analysis. Results: Immunoreactivity of p57 showed 100% sensitivity, specificity, Positive Predictive Value (PPV) and Negative Predictive Value (NPV) respectively in differentiating CHM from PHM. Immunoreactivity of Ki-67 at Grade 0 and grade 1 had a sensitivity of 100% and 92.86% in diagnosing HA respectively. At grade 2, the specificity was 98.18% in diagnosing PHM, but the sensitivity was low compared to grade 1. Grade 3 for diagnosing CHM has good sensitivity of 96.30%, specificity 100%, PPV 100% and NPV 100%. Conclusion: The diagnostic validity of p57 in identifying CHM is most reliable. The diagnostic validity of Ki – 67 showed an overlapping between HA and PHM at grade – 1 level, but PHM cases graded 2 were more reliable, in case of CHM, grade 3 was most reliable, hence making CHM reliably distinct from PHM. Differentiation of molar gestation from hydropic abortus using p57 and ki-67 expression can aid the clinician in planning the treatment strategies