It sole responsibility of anesthetized to have knowledge about the physical and chemical characteristics of every drugs and its role. At foremost the cautious standard of drug delivery technique with continual intravenous procedure isvery importance to avoid inadequate dosage level to the patient. Development of the new prototype based regulated method are able to say about dosage level given to the patient, but they are truly depends upon the patient body nature. So it must have an adequate awareness about characteristic of each drug before it is used to the humanbody. At finally we had review and examine the outcome of collective effect of commonly used two drugs Propofol (hypnotic) and Remifentanil (opioid) and its lustiness and reliability during operation.