Surgical antibiotic prophylaxis is a very brief course of antibiotics initiated closely before the start of operative procedures to reduce postoperative SSI’s. Antibiotic prophylaxis has been shown to be an effective measure for preventing SSIs. This study is to analyse the utilization of antibiotics prescribed for prophylactic treatment among post operative patients. The data were collected by using a pre designed patient proforma. Out of 151 patients 102 were males (67.5%) and 49 (32.5%) were females. The most performed procedure was Appendectomy 24 (15.8%), followed by hernioplasty 19 (12.5%). The total number of antibiotics prescribed were 341, from which Metronidazole was frequently prescribed 102 (29.7%) followed by Ceftriaxone 73 (21.2%) and Amoxicillin-Clavulanic acid 58 (16.9%). Only 30 patients received antibiotics for 24 hours. SSI was developed in 1 out of 151 patients. ADRs were determined in 5 patients. The outcomes underscore the difficulties in integrating evidence- based protocols seamlessly into everyday clinical practice. Addressing this challenge requires collaborative efforts to establish evidence based guidelines with surgeons.