Aim: To assess the attitude of the general population towards the use of E healthcare among the residence of Kerala state, India. Method:A web-based cross-sectional survey was employed. The data was collected using a Google form. The reliability of the tool was found to be high, as it is a highly standardized internationally accepted tool that was used and administered in the month of May 2021. 515 participants joined the study. The researcher’s examined the data using Measures of Central Tendency, Measures of Dispersion, Measures of Normality, and one-way ANOVA. Results: The study revealed that 59% of them have low attitudes, 18% average, and 23% high attitudes. Out of 324 males and 191 females, only 68 persons are having prior experience in E healthcare. Conclusion: the study declares that the residents of Kerala state is having a low attitude towards E healthcare and have no correlation with demographical variables selected.