Background: The integration of digital therapeutics, such as virtual reality (VR) systems, into pediatric healthcare can indeed have a significant impact on managing pain and anxiety associated with medical procedures. The Aim: To determine the effectiveness of VR in reducing anxiety and pain during IV treatment among school going children selected hospital at, Nadiad city Methods: This true experimental study was conducted at the selected hospital at, Nadiad city. The computer assisted simple random sampling technique was used to select 60 school going children. The sample of children (n= 60) was case group (n=30) and the control group (n=30). Hamilton anxiety scale was used to assess the anxiety level during IV treatment in school going children. Face pain scale was used to assess the pain level during IV treatment in school going children. Results: Anxiety and pain were significantly lower in the case group. In the case group, 30% of children reported mild anxiety, 26.7% moderate, 33.3% severe, and 10% very severe. In the control group, 0% had mild anxiety, 6.7% moderate, 20% severe, and 73.3% very severe. Regarding pain, 66.7% of children in the case group reported mild pain, 33.3% moderate, and none severe. In contrast, the control group had 3.3% with mild pain, 56.7% moderate, and 40% severe. This shows that the case group experienced significantly less moderate and severe pain compared to the control group.Conclusion: In this study virtual reality intervention can effectively reduce the anxiety and pain during IV treatment in school going children.