Backround: Osteoarthritis (OA) involves various joint disorders triggered by mechanical stress, with contributions from both genetic and environmental factors. Contemporary views regard OA as a disease impacting the entire joint. Aim: The main aim of the study to assess the level of anxiety and depression among patients with osteoarthritis in selected hospital, Chennai. Methods: The present study was adopted a cross-sectional design. The required sample size was determined to be 185 patients. Using a convenient sampling technique, the sample was selected from osteoarthritis patients who attending the OPD and who are admitted in ward at the selected hospital. Finding: The study revealed that in depressive symptoms, 16.2% (30 patients) experienced mild symptoms, while 83.8% (155 patients) had moderate symptoms. Anxiety symptoms were mild in 18.4% (34 patients) and moderate in 81.6% (151 patients). Conclusion: The study found that osteoarthritis patients experience moderate to high levels of depression and anxiety, with these conditions being positively correlated with the severity of the disease. This correlation is especially significant in women and patients aged 40 years or younger.