The aim of this study was to create chemically cross-linked chondroitin sulfate-co-poly (methacrylic acid) hydrogels (CSH hydrogels) designed for pH-responsive delivery of Carboplatin (CARBP) to the colon. These hydrogels were synthesized using free radical polymerization, where chondroitin sulfate (CS) was cross-linked with methacrylic acid (MAA) in an aqueous solution. Ammonium peroxodisulfate (APS) served as the initiator, and N, N-methylene bisacrylamide (MBA) acted as the cross-linker. The hydrogels were then loaded with CARBP. To characterize the polymeric system, techniques such as FTIR, TGA, DSC, and XRD were employed. Scanning electron microscopy (SEM) was used to examine the surface morphology of the hydrogels. The pH-sensitive properties of the hydrogels were assessed through swelling dynamics and equilibrium swelling ratio at different pH levels. These assessments confirmed the formation of a new polymeric network. Formulations with higher CS content exhibited maximum swelling at pH 7.4. Additionally, high Carboplatin loading and increased drug release were observed at pH 7.4. The study concludes that a stable polymeric network of chondroitin sulfate and methacrylic acid has been successfully created, offering potential as a delivery system for targeting Carboplatin to the colon in colorectal cancer treatment.