AIM: Green chemistry, also known as ecologically sustainable chemistry, is an area of study in chemistry whose major goal is the reduction of the adverse impacts of chemical processes along with products. Objective is supporting the advancement of viable & ecologically therapies by reducing/eliminating the implimentation of noxiuous chemicals, limiting the fabrication of explosive chemicals, along with conserving energy, as well as resources. MATERIAL/METHOD: This investigation found that the concentration range of azelnidipine (AZDN) was linear, ranging from 02 to 12 μg/mL. Having a sample size of six, the recovery %age from tablet formulation was assessed to be 99.6% with a standard deviation (SD) of ± 0.004. The accuracy study inferred recovery rates that, on average, varied between 99.6 and 100.1%. RESULTS: Throughout intra-day assessments, resulting %RSD, showed a value that was significantly less than 2%, stipulating a remarkable range of accuracy in the strategic plan. Such recommended processes can be implemented inside the aided quality control laboratories, according to the results of validation and statistical analyses of the technique. CONCLUSION: The current approach is considered to be appropriate for quantitatively evaluating AZDN in tablet dosage formulations subsequently, it successfully removes any of the possible obstructions among commonly utilized preservative. Therefore, this particular method can be used for routine analytical objectives.