Ameloblastic carcinoma refers to tumors exhibiting ameloblastomatous differentiation and displaying cytological features of malignancy, with or without metastasis. A 52 years old male patient visited with a chief complaint of mobile tooth in his right back tooth region for past 3 months. On examination a grayish-white patch intermixed with erythematous areas was observed on the right buccal mucosa in relation to 47 and 48 along with Grade III mobility, and extraorally a diffuse swelling was evident at the left lower border of the mandible. OPG revealed an ill-defined radiolucency of right side of mandible from mesial root of 48 extending to involve angle of the mandible. Based on histopathological and immunohistochemical examination a final diagnosis of Ameloblastic Carcinoma was made.