Cerebral palsy (CP), a group of motor disorders and cognitive disturbances, is an important health concern in the newborns, particularly in the premature or low-birthweight neonates. CP is likely to lead to the musculoskeletal problems, even epilepsy. Many children with CP have limitations during their daily activities, including feeding, dressing, and balance. Some CP cases are complicated with malnutrition. CP Progression results in an increased morbidity and mortality, which indicates that early prevention and intervention for CP is of great importance. Strenuous efforts have been made to identify the risk factors for CP susceptibility. Birth asphyxia and genetic factors were involved in the development of CP. In spite of the progress of the prenatal diagnosis and interventions, the prevalence of CP did not decline obviously, which indicated that CP may be a multi-factor disease, an in-depth investigation of other potential risk factors for CP is imperative. Trace elements status is closely associated with the immune system function via their effects on many biological Processes, while the well worked immune function required the micronutrients participating in cell metabolism and replication. For instance, leukocytes proliferation induced by acute infection was impaired by insufficient supply of trace elements, including iron, zinc, magnesium and manganese. Trace elements also exerted effects on the cellular transfer and the levels of other important nutrients. For example, iron was an important constituent of hemoglobin, which carried the oxygen and participated in the energy metabolism. It is also proved that certain trace elements affect the chemical synaptic transmission in the brain and peripheral central nervous system. Zn play an important role in the activation of enzymes that are involved in catecholamine transmission.