There are about 125 million musculoskeletal disorders across the world, according to the World Health Organization’s data from thousands of patients lodged in hospitals. These disorders have a degenerative trend and have especially been chronic and cause problems in the motion of joints and muscles. The objective of this study is to determine the functional difference in muscle strength and joint mobility between healthy persons and patients with MSD at Rashid Latif Medical College, Lahore. Procedures for the measurement of joint motion and muscle strength and those for assessing MSDs were conducted on samples of 50 healthy and 50 patients. Contrasting analysis results showed that subjects with MSDs had a restricted range of joint mobility (Mean, 130r, SD=28.6 S=3.0, Max=150.2) than the healthy group (Mean, 150r, SD =4.1 S=5.2; F=229.7, p<0.001). In these tests, the functional ability of the patients with MSDs was generally reduced when compared to the matched group of patients with normative development. These results are consistent with other studies that demonstrate that MSDs restrict functioning of the individuals in an occupational setting. This work emphasizes the need to develop appropriate rehabilitation approaches. Research in the future should strive to restore optimal levels of joint mobility and muscle strength. The study offers novel details employing a transversal method since both parameters are scrutinized at the same time within the said context