Many pyrazole based Schiff base metal complexes were reported to show higher activities towards bacterial, parasitic strains and cancer lines. Metal complexes of Ni (II) with various imines have been synthesized successfully in alcoholic medium. The synthesized imines have been characterized qualitatively by 1H NMR and FTIR spectroscopy. While complexes formed are analyzed by FTIR,elemental analysis and TGA-DSC. The antimicrobial activities of the synthesized complexes were screened against the Staphylococcus aurous, Escherichia coliand Candida albicans. In vitro antibacterial screening activity revealed that the complexes IMN2, IMN3 and IMN4 showed moderate activity against tested bacterial strains. While the complex IMN1 showed excellent activity tested bacterial strains. However, the IMN1 complex at 10 mg/ml revealed excellent activity as compared with other complexes. In addition, the anticancer activity of the complex IMN1 to IMN4 was performed on A549 (Lung Cancer cell line by using standard 5-FU). At the different doses (10 µg/ml to 100 µg/ml) of IMN1, IMN2, IMN3 and IMN4, it was observed that the IC50 value of the compound IMN1 and IMN4 showed good activity against A549 (Lung Cancer cell line) ascompared with standard drug 5 FU. So these results suggest that the pyrazole based Schiff bases will be widely used in cancer treatments in future.