Antibiotic resistance is a major concern in human and veterinary medicine and poses a serious challenge to public health. Mastitis in goats is a frequent pathology that create a lot of problems in dairy farming, and its management imposes the use of ATB for treatment and prevention. However bacterial resistance, especially of S.aureus, a major mastitis pathogen, accelerates research for new drugs. Propolis is a natural bee product with various biological activities, such as antioxidant and antibacterial activity.