Background: Carica Papaya, is a herbaceous plant popularly known as pawpaw. The remarkable reduction activity of the extract of the leaf of the papaya plant can possibly be used for the synthesis of nanoparticles. Recently, Carica papaya has become popular for the formulation of some NPs. Materials and MethodsCommercially available papaya leaf powder (Bixa Botanical) was employed for the green synthesis of nanoparticles. A formulated copper sulphate solution was made by adding 0.314 g of Copper Sulphate powder (LABOGENS pvt limited) to 60 mL of water. This solution was combined with papaya leaf powder using an orbital shaker to create the master solution. Scanning electron microscopy (SEM) analysis was carried out. (JSM-IT800, White Lab, Saveetha Dental College) RESULTSThe copper nanoparticles are successfully synthesised by the papaya leaf extract reducing activity. In the assays for DPPH (67% inhibition for 9µL concentration, 75% inhibition for 20µL, 81% at 30µL, 78% at 40µL, and 88.9% at 50µL concentrations) and H2O2 (56% inhibition at 10µL concentration, 68% at 20µL, 69% at 30µL, 77% at 40µL, and 80% at 50µL concentrations), high values were obtained. ConclusionSince papaya leaf extract has a high concentration of naturally occurring bioactive components and strong antioxidant properties, using it to make copper sulphate nanoparticles is a good substitute for using harmful chemicals. These nanoparticles can be used in impression materials, root canal irrigants, and oral delivery systems.