Polluted groundwater poses a significant threat to human health by compromising water quality. This study investigates the quality and drinking water suitability of groundwater in the Ouargla aquifers, Algeria. This study focused on evaluating the groundwater quality and its suitability for drinking, in Ouargla, Algeria. For this purpose, seventy-two shallow groundwater samples were sampled during 2024. Physical and chemical parameters of groundwater such as electrical conductivity, pH, temperature, Ca2+, Na+, K+, Mg2+, HCO3-, SO42-, Cl-, and NO3- were determined. The calculation results of entropy weighted water quality index (EWQI) showed that about 66.66% of groundwater samples are unfit for drinking purposes. The results indicate that applying the EWQI is useful for helping the public and decision-makers identify and evaluate groundwater quality in Ouargla, solve groundwater pollution problems, and ensure healthy drinking water in this basin and other similar regions worldwide.