Background: Dental implants are a widely used and effective solution for replacing missing teeth. The present study was conducted to assess success rate of dental implants in medically compromised patients. Material & Methods: 56 medically compromised patients of both genders who had received dental implants 10 years back were selected. Equal number of healthy subjects was taken as control. The amount of bone loss around the implant, signs of infection and level of bone around the implant were recorded. Success rate was assessed. Results: Group I had 80 dental implants and group II had 110 implants. In group I, 24 patients were diabetic, 14 had hypertension, 6 had CVD, 4 had osteoporosis and 6 had hypothyroidism. The difference was significant (P<0.05). Success rate in group I was 64% and I group II was 95%. The difference was significant (P< 0.05). Conclusion: Dental implant treatment results are impacted by a poor medical status. Patients with conditions including diabetes, osteoporosis, hypothyroidism, etc. had a decreased chance of surviving than patients in good health.