Background: Stroke, a significant global health concern, ranks among the leading causes of morbidity, mortality, and long-term disability. Insulin resistance(IR) is a hallmark of metabolic syndrome and is considered to be one of the important risk factors of stroke. Insulin resistance (IR) is prevalent in patients with stroke. The triglyceride-glucose (TyG) index has been proposed as the alternative indicator of IR due to its relevance to lipotoxicity and glucotoxicity. Aim: The study aimed to evaluate the association of triglyceride glucose with clinical outcomes in ischemic stroke. The Primary Objective is to evaluate the relationship between high TyG indexes and adverse clinical outcomes in patients with Ischemic stroke. The Secondary objective is to identify the prevalence of adverse outcomes (Recurrence and all-cause mortality) in patients with ischemic stroke. Method: This is a retrospective observational study which was carried out for a period of 6 months in patients admitted to Dr. pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation which is a 850 bedded tertiary care teaching hospital at Chinnaoutpalli, Gannavaram Mandal, Krishna district, Andhra Pradesh (India). A total of 95 patients who met the inclusion criteria were recruited into the study Results:In this study, the plasma lipid profile of patients, that is Total cholesterol was found to be 165.01 ± 51.5 mg/dL; Triglycerides was 157.031 ± 98.9 mg/dL; HDL-c was 37.253 ± 5.52mg/dl; LDL-c was 107 ± 48.3mg/Dl; and FBS was 153.74 ± 71.52 mg/dL. Conclusion: Few studies showed that there is a significant association between TyG Index and cardiovascular outcomes, but according to our study, we conclude that there may be no significant association between and clinical outcomes in ischemic stroke patients.