This study investigates the relationship between morphological variations in the Circle of Willis (CoW0 and cerebrovascular diseases (CVD), focusing on the structural anomalies and their correlation with disease outcomes. The objective was to analyze how different morphological configurations of the CoW influence the incidence and severity of CVDs, including ischemic strokes and aneurysms. The results revealed that structural abnormalities, such as hypoplastic or absent arteries in the CoW, were statistically significant risk factors for increased susceptibility to cerebrovascular events. A total of 150 patients were included, with a focus on angiographic imaging to identify variations in the CoW's structure. Statistical analysis, including the Chi-square test and multivariate logistic regression, demonstrated significant associations between specific CoW anomalies and CVD outcomes, with a p-value < 0.05 indicating robust statistical significance. This study highlights the need for early screening of individuals with CoW anomalies, as these variations can serve as biomarkers for predisposition to cerebrovascular diseases. The findings suggest a potential pathway for personalized risk assessment and intervention strategies. In conclusion, the morphological variations in the CoW provide significant insights into cerebrovascular disease pathogenesis, underscoring the importance of early detection and preventative measures.