Aim: The objective of the present investigation was to extract the mucilage from flower petals of Bombax Ceiba and explore its use as a promising excipient for Pharmaceutical preparation. Natural polymers have constantly a remarkable property which makes them particular from synthetic polymer and Bombax Ceiba flower mucilage is one such model that shows increasingly important properties making it a helpful excipient for a wide scope of utilizations. Materials and Methods: The flowers of Bombax Ceiba were collected from the Regional Ayurveda Research Institute for Drug Development (RARIDD), Gwalior region of India and were authenticated at the Botanical Survey of India, Central Regional Centre, Allahabad, U.P (Authentication voucher No. B.S.I/C.R.C/TECH./2018-19/559 with Accession No. 103976).Bombax Ceiba flower petals mucilage is isolated by the Microwave-assisted method and tablet prepared by Experimental runs were designed by Design Expert 10.0.1 [Stat Ease.Inc.] software following full factorial method. 32 full factorial designs were applied for examining two variables (factors) at three levels with a minimum of 9 runs. The tablets containing paracetamol as the main active constituent were prepared by a wet granulation method using isolated mucilage in different composition (F1 – F9) or starch (F10) or PVP K 30 (F11) as an internal binder.