In Algeria, goat farming is one of the most important agricultural activities, linked to the breeding of small ruminants, and plays an important role in human nutrition thanks to its meat, hair and milk. Many profitable breeds arrived in Algeria for adaptation and crossbreeding to improve local population, including the Alpine breed. Our aim was to analyze the functioning of the goatherd in the Oases, and we focused on the impact of physiological stage on the biological biomarkers that reflect the adaptability of the Alpine breed. This work was carried out on 46 Alpine goats belonging to a state-owned farm [Technological Institute for the Development of Saharan Agriculture (T.I.D.S.A.)] located in the commune of El-hajeb, wilaya of Biskra, (North-East Algeria). Samples came from clinically healthy goats at different physiological stages (23 pregnant, 23 lactating). Circulating concentrations of TP, ASAT, ALAT, ALP, TC and Glucose were determined .Statistical analysis of the results showed that ALAT levels were significantly lower in lactating than in pregnant goats, while alkaline phosphatase and glycemic levels were significantly higher in lactating than in pregnant goats. As a result, concentrations of total protein, ASTAT and cholesterol did not show significant differences between the two stages of the goats.