The liver is the largest gland in the body, weighing approximately 1500 g. It is located in the upper right-hand quadrant of the abdominal cavity, just inferior to the diaphragm. The liver is subdivided into four lobes (right, left, quadrate, and caudate) of which the first two constitute its bulk. It is completely enveloped by peritoneum except its bare area. Hepatocytes are arranged in such a manner that each cell not only comes in contact with other hepatocytes but also borders the space of Disse. Thus, the plasma lemma of hepatocytes to have lateral and sinusoidal domains. The lateral domains of the hepatocyte cell membrane from labyrinthine intercellular space ,1 to 2 μm in diameter, known as bile canaliculi lobules. leakage of bile from bile canaliculi is prevented by the formation of tight junctions between adjoining liver cells. At the sinusoidal domain, microvilli projecting from basal surface of hepatocytes increase the surface area available for exchange of materials between hepatocytes and plasma by much as six times. The epithelial cells of the canals of Hering and of the bile ducts secrete a bicarbonate-rich fluid like that produced by the duct system of the pancreas. The formation and release of this alkaline buffer is controlled by the hormone secretin, produced by diffuse neuroendocrine system (DNES) cells of the duodenum. This fluid acts with fluid from the pancreas, to neutralize the acidic chyme that enters the duodenum