INTRODUCTION: A bidirectional relationship between kidney disease and periodontitis has been proposed a link to endothelial dysfunction and decrease of renal function. Patients with periodontitis have a significantly higher risk of chronic kidney disease than do healthy individuals. Salivary creatinine and urea could be used as noninvasive markers for assessment of kidney function and diagnostics of renal failure. OBJECTIVE: To assess and correlate the salivary urea and creatinine levels among patients with and without periodontitis in diagnosing chronic kidney disease. METHODOLOGY: This case-control study was conducted among patients attending a tertiary hospital in the age group of 40–60yrs with 26 samples in each group with periodontitis and without periodontits. All participants were instructed to avoid eating or drinking for 2 hours before collection of saliva. Whole saliva was collected by spitting method. Saliva samples were stored at -20°C until laboratory analysis. Samples were defrosted at room temperature and then centrifuged at 3000 rpm for 10 min before being used for the analysis in order to remove contaminants. RESULTS: The mean values of salivary creatinine levels were 0.71mg/dl and salivary urea levels were 94.28 mg/dl among cases. The mean values of salivary creatinine level were 0.09mg/dl and salivary urea levels were 16.28 mg/dl among controls. CONCLUSION: There was a positive correlation between salivary creatinine and urea levels among Chronic Kidney Disease patients thus stating saliva can be used as a noninvasive diagnostic tool for estimating the urea & creatinine level among periodontitis patients with Chronic Kidney Disease.