Some chemicals don't dissolve well or don't let much through, which makes it hard to make goods that are bioavailable when taken by mouth. Nanotechnology is supposed to make our lives and living conditions a lot better.Acetonitrile was used as the solvent in this method, and Millipore water is used as the antisolvent. PVP and HPMC were the detergents that were used in the mix. It was discovered that these surfactants worked well together in the mixture. FTIR spectroscopy was used to check how well the medicine and its ingredients worked together. The study showed that the cefixime nanosuspension helped the most with healing. A variety of techniques were used to study the improved cefixime nanosuspension, including particle size analysis, differential scanning calorimetry, zeta potential, drug content, in vitro drug release research, scanning electron microscopy, and transmission electron microscopy. The disk diffusion method was used to test Cefixime nanosuspensions antibacterial action against E. coli on nutritional agar at different doses.It could also be said that the nanosuspension form of cefixime is more bioavailable when taken by mouth than the medicine itself.