This article presents theoretical information about biologically active substances of the local Jerusalem artichoke variety created in the Uzbek Research Institute of Plant Growing. Carbohydrates, proteins and lipids have been studied. As a raw material, air-dry crushed raw materials were used separately (leaves, stems and roots). The quantitative content of lipids, mono and oligosaccharides, water-soluble polysaccharides, pectin substances and hemicellulose was determined. The qualitative monosaccharide composition and physico-chemical properties were established, the amino acid composition was determined. Classes of neutral glyco and phospholipids and their fatty acid composition were determined. It has been shown that syrup from tubers exhibits hypoglycemic activity.